Pericardium development

Across TCGA cell cohorts, RNA activity of the Pericardium development pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGIF1, PRKRA, and LRRC36, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TGIF1 grouped by Pericardium development-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TGIF1 →	+0.977	+0.915	.001	.005	3	4
PANCREAS	PRKRA →	+0.558	+1.022	.001	.001	3	4
CNS	LRRC36 →	+0.240	+0.966	.001	.001	3	4
BONE	UBXN1 →	+0.852	+1.515	.002	<.001	3	4
BONE	H3-3A →	+0.853	+1.603	.002	<.001	3	4
LARGE_INTESTINE	MTHFR →	+0.638	+1.030	.004	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TGIF1 by Pericardium development activity — PANCREAS

Explore this box plot interactively →