Cardiac muscle cell proliferation

Across TCGA patient cohorts, RNA activity of the Cardiac muscle cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LAML cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA9, ADGRA2, and SHPRH, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac muscle cell proliferation activity versus ITGA9 in LAML (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	ITGA9 →	+1.363	+0.047	<.001	<.001	3	31
TGCT	ADGRA2 →	+1.838	+0.060	<.001	<.001	3	31
THYM	SHPRH →	+0.760	+0.034	<.001	<.001	3	31
UCS	QKI →	+1.357	+0.069	<.001	<.001	3	30
UCS	RECK →	+1.101	+0.059	<.001	.001	2	31
DLBC	MED13L →	+1.177	+0.032	<.001	.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060038 vs ITGA9 — LAML

Explore this scatter interactively →