Cardiac muscle cell proliferation

Across TCGA patient cohorts, RNA activity of the Cardiac muscle cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AVEN, SMO, and COL8A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac muscle cell proliferation activity versus AVEN in LSCC (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AVEN →	+0.220	+0.516	.008	.001	3	5
UCEC	SMO →	+0.483	+0.497	.005	.002	3	4
GBM	COL8A1 →	+1.262	+0.756	.003	.002	3	4
CCRCC	LRRC77P →	+0.533	+1.130	<.001	<.001	3	4
CCRCC	CASC15 →	+0.544	+0.743	.005	.004	3	4
CCRCC	EMP1 →	+0.819	+0.679	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060038 vs AVEN — LSCC

Explore this scatter interactively →