Cardiac muscle cell proliferation

Across TCGA cell cohorts, RNA activity of the Cardiac muscle cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF671, FAM193B, and TSPAN15, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF671 grouped by Cardiac muscle cell proliferation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ZNF671 →	+0.566	+0.640	.005	.002	3	4
KIDNEY	FAM193B →	+1.242	+1.212	.003	.009	3	4
CNS	TSPAN15 →	+1.670	+1.078	.009	.003	2	5
CNS	TAF8 →	+0.375	+0.970	.005	.001	3	4
SOFT_TISSUE	MREG →	+1.258	+1.080	.004	.005	3	3
SOFT_TISSUE	MICOS13 →	-0.792	-1.021	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF671 by Cardiac muscle cell proliferation activity — BREAST

Explore this box plot interactively →