Pharyngeal system development

Across TCGA patient cohorts, RNA activity of the Pharyngeal system development pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGEF17, BIN2, and SRA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pharyngeal system development activity versus ARHGEF17 in CCRCC (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ARHGEF17 →	+0.372	+0.078	<.001	<.001	3	6
UCEC	BIN2 →	-0.457	-0.065	.009	.001	3	6
COAD	SRA1 →	-0.275	-0.035	.002	.002	3	6
PDAC	PTPN6 →	-0.311	-0.041	.001	.002	3	6
CCRCC	DOCK9 →	+0.226	+0.075	<.001	<.001	3	6
LUAD	DTNB →	+0.361	+0.059	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060037 vs ARHGEF17 — CCRCC

Explore this scatter interactively →