Pharyngeal system development

Across TCGA cell cohorts, RNA activity of the Pharyngeal system development pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB24, LIN52, and BAG4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZBTB24 grouped by Pharyngeal system development-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ZBTB24 →	+0.634	+0.905	.006	.002	3	5
LUNG_SCLC	LIN52 →	+0.816	+0.266	.007	.008	3	5
LARGE_INTESTINE	BAG4 →	+0.710	+0.663	.001	.001	3	5
PANCREAS	MFN1 →	+0.517	+0.707	<.001	.004	3	4
LUNG_SCLC	ZBTB8A →	+1.062	+0.245	.001	.004	3	4
KIDNEY	PAX9 →	+0.436	+0.702	.003	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZBTB24 by Pharyngeal system development activity — OVARY

Explore this box plot interactively →