Pharyngeal system development

Across TCGA cell cohorts, RNA activity of the Pharyngeal system development pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYO3A, UBA1, and TPP2, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MYO3A grouped by Pharyngeal system development-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MYO3A →	+0.110	+0.457	<.001	.007	3	2
CNS	UBA1 →	-0.423	-0.350	.004	.002	3	2
CNS	TPP2 →	-0.473	-0.350	.002	.002	3	2
LUNG_NSCLC_LUAD	NANOG →	-0.268	-0.457	<.001	.007	3	2
LUNG_NSCLC_LUAD	MYL12B →	-0.386	-0.457	<.001	.007	3	2
LUNG_NSCLC_LUAD	GSTM5 →	+0.406	+0.650	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MYO3A by Pharyngeal system development activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →