Pharyngeal system development

Across TCGA cell cohorts, RNA activity of the Pharyngeal system development pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHML, KLK10, and CRABP1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pharyngeal system development activity versus CHML in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CHML →	+1.820	+0.419	.002	.008	3	3
CNS	KLK10 →	+0.277	+0.588	.004	.003	3	2
CNS	CRABP1 →	+0.252	+0.442	.004	<.001	3	2
CNS	MILR1 →	+1.813	+0.524	.001	<.001	3	2
BREAST	RPS6KA5 →	+1.376	+1.620	.006	.009	3	2
BREAST	BARHL1 →	+0.033	+1.036	.009	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060037 vs CHML — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →