Soft palate development

Across TCGA patient cohorts, RNA activity of the Soft palate development pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TPST2, BEND3, and EHD2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Soft palate development activity versus TPST2 in COAD (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TPST2 →	-0.701	-0.202	.003	.002	3	5
BRCA	BEND3 →	+0.328	+0.069	<.001	<.001	3	5
GBM	EHD2 →	-0.488	-0.081	<.001	.004	3	5
BRCA	HGF →	-0.389	-0.056	.001	.001	3	5
LSCC	OSMR_S826 →	-0.718	-0.074	<.001	.002	3	5
COAD	POSTN →	-0.821	-0.081	.001	.003	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060023 vs TPST2 — COAD

Explore this scatter interactively →