Soft palate development

Across TCGA patient cohorts, RNA activity of the Soft palate development pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSHZ1, GSTA4, and CYP39A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Soft palate development activity versus TSHZ1 in UCEC (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TSHZ1 →	+1.073	+0.502	<.001	.002	3	6
HNSC	GSTA4 →	+1.142	+0.426	.004	.002	3	5
BRCA	CYP39A1 →	-1.118	-0.218	.002	.005	3	5
GBM	MAGI1 →	+0.835	+0.456	<.001	<.001	3	5
GBM	GPR37 →	-1.067	-0.305	<.001	<.001	3	5
LSCC	NFAM1 →	-0.485	-0.447	.009	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060023 vs TSHZ1 — UCEC

Explore this scatter interactively →