Soft palate development

Across TCGA cell cohorts, RNA activity of the Soft palate development pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLE1, DENND5A, and PAX8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GLE1 grouped by Soft palate development-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	GLE1 →	-0.683	-0.247	.009	.005	3	4
LUNG_SCLC	DENND5A →	-1.063	-0.334	.003	<.001	3	4
OESOPHAGUS	PAX8 →	-1.351	-0.269	.005	<.001	3	3
OESOPHAGUS	PGAP4 →	-2.911	-0.346	<.001	.001	3	3
OESOPHAGUS	ARL17A →	+1.174	+0.202	.001	.002	2	4
OESOPHAGUS	LRRC37A2 →	+1.194	+0.199	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GLE1 by Soft palate development activity — PANCREAS

Explore this box plot interactively →