Roof of mouth development

Across TCGA patient cohorts, RNA activity of the Roof of mouth development pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPRG, ITGAL, and TBX3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Roof of mouth development activity versus PTPRG in CCRCC (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PTPRG →	+0.906	+0.461	<.001	.001	3	6
HNSC	ITGAL →	-0.946	-0.190	<.001	.001	3	6
BRCA	TBX3 →	+1.372	+0.292	<.001	<.001	2	6
BRCA	PSMB10 →	-0.827	-0.403	.001	.004	3	5
CCRCC	IFNG →	-0.945	-0.236	.001	.004	3	5
CCRCC	APBB2 →	+0.690	+0.451	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060021 vs PTPRG — CCRCC

Explore this scatter interactively →