Radial glial cell differentiation

Across TCGA patient cohorts, RNA activity of the Radial glial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMP5, LEF1, and FKBP10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Radial glial cell differentiation activity versus LAMP5 in LSCC (Pearson r = 0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LAMP5 →	+0.595	+0.130	.005	.002	3	3
LSCC	LEF1 →	+0.609	+0.196	.003	.001	3	3
LSCC	FKBP10 →	+0.684	+0.143	.004	.006	3	3
LSCC	PGD →	-0.908	-0.167	.001	<.001	2	4
HNSC	ID3 →	+0.676	+0.238	.008	.004	3	3
BRCA	KMO →	-0.924	-0.439	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060019 vs LAMP5 — LSCC

Explore this scatter interactively →