Radial glial cell differentiation

Across TCGA cell cohorts, RNA activity of the Radial glial cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAD21, TAAR2, and MED7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAD21 grouped by Radial glial cell differentiation-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	RAD21 →	+0.376	+0.099	.008	.007	3	5
PANCREAS	TAAR2 →	-0.130	-0.116	.002	.001	3	5
LUNG_NSCLC_LUSC	MED7 →	+0.527	+0.141	.009	.003	3	4
PANCREAS	ATP4A →	+0.272	+0.134	.006	.009	3	4
LUNG_NSCLC_LUAD	GOT2 →	-0.152	-0.106	.001	.008	3	4
LUNG_NSCLC_LUAD	DGKQ →	+0.193	+0.116	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAD21 by Radial glial cell differentiation activity — KIDNEY

Explore this box plot interactively →