Radial glial cell differentiation

Across TCGA cell cohorts, RNA activity of the Radial glial cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CACNG7, TOX2, and BRDT, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CACNG7 grouped by Radial glial cell differentiation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CACNG7 →	+0.218	+0.345	.001	.001	3	4
OVARY	TOX2 →	+0.286	+0.429	.005	<.001	3	3
BREAST	BRDT →	+0.209	+0.300	.008	.005	2	4
LUNG_SCLC	DEDD2 →	+0.110	+0.290	.003	.001	3	3
BLOOD_Leukemia	RBKS →	-0.297	-0.328	.009	.006	3	3
LARGE_INTESTINE	TNFRSF1A →	-0.101	-0.413	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CACNG7 by Radial glial cell differentiation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →