Parathyroid gland development

Across TCGA patient cohorts, RNA activity of the Parathyroid gland development pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGFBR1, ZNF8, and HOXA2, each associated with the pathway in up to 22 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Parathyroid gland development activity versus TGFBR1 in UVM (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	TGFBR1 →	+1.153	+0.101	<.001	<.001	3	22
TGCT	ZNF8 →	+0.525	+0.056	<.001	<.001	3	18
THYM	HOXA2 →	+1.517	+0.077	<.001	<.001	3	17
UVM	ZNF292 →	+1.232	+0.130	<.001	<.001	3	17
UVM	CEP290 →	+1.090	+0.126	<.001	<.001	3	16
LAML	HOXA3 →	+1.911	+0.086	<.001	<.001	2	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060017 vs TGFBR1 — UVM

Explore this scatter interactively →