Parathyroid gland development

Across TCGA patient cohorts, RNA activity of the Parathyroid gland development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DMXL1_S1896, ESF1_S663, and YIF1A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Parathyroid gland development activity versus DMXL1_S1896 in BRCA (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DMXL1_S1896 →	+0.584	+0.100	.002	<.001	3	6
PDAC	ESF1_S663 →	-0.720	-0.070	.003	.005	3	5
BRCA	YIF1A →	+0.348	+0.068	<.001	<.001	3	5
PDAC	CEP170_S359 →	-0.956	-0.086	<.001	<.001	3	5
BRCA	RAB3D →	+0.724	+0.120	<.001	<.001	3	5
PDAC	CTBP1 →	-0.329	-0.068	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060017 vs DMXL1_S1896 — BRCA

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