Parathyroid gland development

Across TCGA cell cohorts, RNA activity of the Parathyroid gland development pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAAP24, PTRHD1, and SKOR1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAAP24 grouped by Parathyroid gland development-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FAAP24 →	+0.619	+0.975	<.001	.005	3	5
LUNG_NSCLC_LUAD	PTRHD1 →	+0.457	+0.537	.004	.004	3	4
BONE	SKOR1 →	+0.339	+1.596	.001	<.001	3	4
LARGE_INTESTINE	PLK4 →	+0.870	+1.060	.002	.002	3	4
LARGE_INTESTINE	C8orf33 →	+0.662	+1.223	.003	<.001	3	4
OVARY	DIS3L →	+1.083	+1.469	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAAP24 by Parathyroid gland development activity — SKIN

Explore this box plot interactively →