Sertoli cell development

Across TCGA patient cohorts, RNA activity of the Sertoli cell development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPIF, TEFM, and CLUH, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sertoli cell development activity versus PPIF in OV (Pearson r = -0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PPIF →	-0.513	-0.062	.002	.001	2	7
LSCC	TEFM →	-0.337	-0.058	<.001	<.001	3	6
UCEC	CLUH →	-0.343	-0.083	<.001	<.001	3	6
UCEC	FER →	+0.283	+0.098	<.001	<.001	3	6
UCEC	LMNA →	+0.455	+0.068	.003	.001	3	6
UCEC	LRPPRC →	-0.351	-0.072	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060009 vs PPIF — OV

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