Sertoli cell differentiation

Across TCGA patient cohorts, RNA activity of the Sertoli cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPP1R13L, TFDP1_S23, and CLSTN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sertoli cell differentiation activity versus PPP1R13L in LSCC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PPP1R13L →	+0.510	+0.076	<.001	<.001	3	6
BRCA	TFDP1_S23 →	-0.809	-0.056	<.001	.001	3	5
BRCA	CLSTN1 →	+0.532	+0.064	.001	<.001	3	5
PDAC	EPB41_S95 →	-0.775	-0.050	.001	.001	3	5
OV	CLPX →	-0.183	-0.048	<.001	.003	3	5
CCRCC	DAPK1_S289 →	-0.443	-0.043	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060008 vs PPP1R13L — LSCC

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