Sertoli cell differentiation

Across TCGA cell cohorts, RNA activity of the Sertoli cell differentiation pathway is significantly associated with the total protein of multiple features, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Rb, Bax, and c-Met_pY1235, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sertoli cell differentiation activity versus Rb in BLOOD_Leukemia (Pearson r = 0.59).

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Rb →	+0.557	+0.101	.018	.029	1	1
BLOOD_Leukemia	Bax →	+0.592	+0.101	.003	.029	1	1
BLOOD_Leukemia	c-Met_pY1235 →	-0.303	-0.101	.005	.029	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest associations by consensus.

GO:0060008 vs Rb — BLOOD_Leukemia

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