Sertoli cell differentiation

Across TCGA cell cohorts, RNA activity of the Sertoli cell differentiation pathway is significantly associated with the drug response of multiple features, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are GSK-LSD1, PCI-34051, and 123829, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GSK-LSD1 grouped by Sertoli cell differentiation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GSK-LSD1 →	+1.117	+0.198	.014	.040	3	1
BLOOD_Leukemia	PCI-34051 →	+0.708	+0.198	.003	.040	3	1
BLOOD_Leukemia	123829 →	+1.239	+0.198	.011	.040	3	1
BLOOD_Leukemia	L-Oxonoreleagnine →	+0.361	+0.198	.035	.040	3	1
BLOOD_Leukemia	GSK591 →	+0.622	+0.198	.036	.040	3	1
BLOOD_Leukemia	PF-00299804 →	+0.265	+0.198	.001	.040	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GSK-LSD1 by Sertoli cell differentiation activity — BLOOD_Leukemia

Explore this box plot interactively →