L-proline biosynthetic process

Across TCGA patient cohorts, RNA activity of the L-proline biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STC2, PYCR1, and RCC2P4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-proline biosynthetic process activity versus STC2 in GBM (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	STC2 →	+0.964	+0.108	.004	.002	3	7
HNSC	PYCR1 →	+1.156	+0.161	<.001	<.001	3	6
LSCC	RCC2P4 →	+0.546	+0.085	.001	<.001	3	6
LSCC	PUS7 →	+0.586	+0.101	<.001	<.001	3	6
LSCC	NANP →	+0.465	+0.101	<.001	<.001	3	6
HNSC	CENPM →	+0.730	+0.123	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055129 vs STC2 — GBM

Explore this scatter interactively →