L-proline biosynthetic process

Across TCGA cell cohorts, RNA activity of the L-proline biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTC21A, ISCA2, and SMIM1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TTC21A grouped by L-proline biosynthetic process-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TTC21A →	-0.789	-0.968	<.001	.002	3	4
SOFT_TISSUE	ISCA2 →	-0.558	-1.167	.002	.003	3	3
SOFT_TISSUE	SMIM1 →	-2.866	-1.420	.003	.004	3	3
BREAST	ABHD11 →	-1.274	-0.936	.002	.002	2	4
BREAST	SOS1 →	+0.495	+0.776	.006	.002	3	3
BREAST	KLRG1 →	+0.680	+1.020	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TTC21A by L-proline biosynthetic process activity — PANCREAS

Explore this box plot interactively →