L-proline biosynthetic process

Across TCGA cell cohorts, RNA activity of the L-proline biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BTBD1, FUT11, and TPGS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-proline biosynthetic process activity versus BTBD1 in CNS (Pearson r = -0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	BTBD1 →	-0.556	-0.396	.006	.003	3	5
SOFT_TISSUE	FUT11 →	-0.852	-0.579	.003	<.001	3	4
SOFT_TISSUE	TPGS1 →	-1.197	-0.384	.007	.003	3	4
LUNG_NSCLC_LUSC	ELP3 →	-0.644	-0.361	.008	.005	3	4
BREAST	NEURL4 →	-0.678	-0.235	.006	.003	3	4
BLOOD_Leukemia	UBAP1L →	-0.718	-0.537	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055129 vs BTBD1 — CNS

Explore this scatter interactively →