L-proline biosynthetic process

Across TCGA cell cohorts, RNA activity of the L-proline biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are OAT, PYCR2, and ALDH18A1, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-proline biosynthetic process activity versus OAT in BONE (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	OAT →	+2.743	+0.549	<.001	<.001	3	18
BLOOD_Leukemia	PYCR2 →	+1.444	+0.813	<.001	<.001	3	17
BONE	ALDH18A1 →	+1.069	+0.639	<.001	.003	3	14
URINARY_TRACT	PYCR1 →	+2.551	+0.601	.001	<.001	3	13
OVARY	EIF4H →	-1.499	-0.353	.002	<.001	3	12
STOMACH	HINT1 →	-2.531	-0.420	<.001	.006	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055129 vs OAT — BONE

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