Digestive system development

Across TCGA patient cohorts, RNA activity of the Digestive system development pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF561-AS1, ZNF844, and MIEF2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Digestive system development activity versus ZNF561-AS1 in GBM (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ZNF561-AS1 →	+0.415	+0.867	<.001	.001	3	5
UCEC	ZNF844 →	+0.392	+0.802	<.001	<.001	3	5
BRCA	MIEF2 →	+0.539	+0.781	.004	<.001	3	5
LUAD	ALKBH3 →	+0.467	+0.514	<.001	.001	3	4
LUAD	PRKD1 →	+0.580	+0.451	.005	.003	3	4
UCEC	ZNF790 →	+0.538	+0.858	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055123 vs ZNF561-AS1 — GBM

Explore this scatter interactively →