Relaxation of cardiac muscle

Across TCGA cell cohorts, RNA activity of the Relaxation of cardiac muscle pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RSBN1, ZMYM4, and GPRASP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RSBN1 grouped by Relaxation of cardiac muscle-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RSBN1 →	-0.778	-1.019	<.001	.003	2	4
CNS	ZMYM4 →	-0.399	-0.222	.008	.005	3	3
PANCREAS	GPRASP2 →	-1.304	-1.146	.001	.005	3	3
BREAST	GFOD1 →	-0.942	-0.252	.004	.006	3	3
STOMACH	MMP14 →	-2.201	-0.206	.003	.002	3	3
PANCREAS	MRPL33 →	-0.669	-1.055	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RSBN1 by Relaxation of cardiac muscle activity — LUNG_SCLC

Explore this box plot interactively →