Relaxation of cardiac muscle

Across TCGA cell cohorts, RNA activity of the Relaxation of cardiac muscle pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PERP, JUP, and PLEKHG6, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Relaxation of cardiac muscle activity versus PERP in STOMACH (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PERP →	+1.523	+0.284	.006	.004	3	8
STOMACH	JUP →	+2.633	+0.289	.008	.003	3	7
LIVER	PLEKHG6 →	+2.454	+0.237	.005	.001	3	7
OESOPHAGUS	ATP1B1 →	+1.860	+0.269	.001	.001	3	7
LIVER	SCARB2 →	+0.999	+0.246	.005	.001	3	6
BLOOD_Leukemia	PRKCD →	+2.201	+0.348	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055119 vs PERP — STOMACH

Explore this scatter interactively →