Negative regulation of cardiac muscle contraction

Across TCGA patient cohorts, RNA activity of the Negative regulation of cardiac muscle contraction pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TBC1D2B, BTK, and CLIC2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cardiac muscle contraction activity versus TBC1D2B in GBM (Pearson r = 0.55).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TBC1D2B →	+0.363	+0.094	<.001	<.001	3	10
LSCC	BTK →	+0.541	+0.102	<.001	<.001	3	9
BRCA	CLIC2 →	+0.678	+0.062	<.001	<.001	3	9
GBM	DAB2 →	+0.584	+0.071	<.001	<.001	3	9
GBM	DOCK2 →	+0.531	+0.078	<.001	<.001	3	9
GBM	GRAP2 →	+0.911	+0.173	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055118 vs TBC1D2B — GBM

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