Negative regulation of cardiac muscle contraction

Across TCGA cell cohorts, RNA activity of the Negative regulation of cardiac muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BIN1, ZC3H12A, and HKDC1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cardiac muscle contraction activity versus BIN1 in BONE (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	BIN1 →	+2.148	+0.221	.006	.001	3	12
URINARY_TRACT	ZC3H12A →	+1.981	+0.268	<.001	<.001	3	11
STOMACH	HKDC1 →	+2.327	+0.150	.006	.001	3	8
KIDNEY	IRAK2 →	+1.456	+0.200	.007	.003	3	7
URINARY_TRACT	CXCL3 →	+2.070	+0.223	.004	<.001	2	8
UPPER_AERODIGESTIVE_TRACT	APOL1 →	+2.902	+0.194	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055118 vs BIN1 — BONE

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