Regulation of cardiac muscle contraction

Across TCGA cell cohorts, RNA activity of the Regulation of cardiac muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APOL3, TGFB1, and CLTA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, APOL3 grouped by Regulation of cardiac muscle contraction-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	APOL3 →	+1.202	+0.794	.008	.002	3	4
LUNG_NSCLC_LUAD	TGFB1 →	-1.328	-0.879	.008	<.001	3	3
KIDNEY	CLTA →	-0.529	-0.917	.008	.003	3	3
LUNG_NSCLC_LUAD	NARS1 →	+0.559	+0.630	.001	.009	3	3
LUNG_NSCLC_LUAD	SLC40A1 →	+1.141	+0.487	.005	.007	3	3
UPPER_AERODIGESTIVE_TRACT	HSPA5 →	-1.040	-1.121	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

APOL3 by Regulation of cardiac muscle contraction activity — LARGE_INTESTINE

Explore this box plot interactively →