Regulation of cardiac muscle contraction

Across TCGA cell cohorts, RNA activity of the Regulation of cardiac muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SH2D3A, DLG4, and KCNK1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cardiac muscle contraction activity versus SH2D3A in URINARY_TRACT (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SH2D3A →	+3.144	+0.313	.008	.008	3	7
LUNG_NSCLC_LUAD	DLG4 →	-0.853	-0.168	.006	.002	3	7
STOMACH	KCNK1 →	+3.415	+0.313	<.001	.002	3	7
LUNG_SCLC	EPS8L2 →	+3.387	+0.429	<.001	<.001	3	7
STOMACH	NIPAL1 →	+1.614	+0.455	<.001	<.001	3	7
OVARY	HSH2D →	+1.351	+0.267	.004	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055117 vs SH2D3A — URINARY_TRACT

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