Response to hyperoxia

Across TCGA patient cohorts, RNA activity of the Response to hyperoxia pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPRASP2, LMAN2L, and NCKAP5-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to hyperoxia activity versus GPRASP2 in PDAC (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	GPRASP2 →	-0.424	-0.182	<.001	<.001	3	4
LSCC	LMAN2L →	-0.288	-0.155	.001	.005	3	4
UCEC	NCKAP5-AS1 →	-0.479	-0.178	.001	<.001	3	3
OV	FAM220BP →	-0.246	-0.197	<.001	.001	3	3
COAD	RPL31P58 →	+0.211	+0.364	<.001	<.001	3	3
HNSC	AKAP1 →	+0.505	+0.142	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055093 vs GPRASP2 — PDAC

Explore this scatter interactively →