Response to hyperoxia

Across TCGA cell cohorts, RNA activity of the Response to hyperoxia pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALKBH6, ODR4, and TMEM161B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ALKBH6 grouped by Response to hyperoxia-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ALKBH6 →	-0.513	-0.514	.009	.007	3	4
KIDNEY	ODR4 →	-0.468	-0.251	.003	.004	3	3
BLOOD_Leukemia	TMEM161B →	+1.406	+1.316	.001	.002	3	3
LARGE_INTESTINE	CDK7 →	+0.711	+1.042	.001	.003	3	3
LARGE_INTESTINE	OAZ3 →	-0.410	-0.925	.005	.009	3	3
LUNG_NSCLC_LUAD	RFPL2 →	-0.248	-0.394	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ALKBH6 by Response to hyperoxia activity — OVARY

Explore this box plot interactively →