Response to hyperoxia

Across TCGA cell cohorts, RNA activity of the Response to hyperoxia pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF4E3, ZNF571, and PXMP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to hyperoxia activity versus EIF4E3 in CNS (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	EIF4E3 →	+1.090	+0.223	<.001	<.001	3	4
BLOOD_Myeloma	ZNF571 →	+1.163	+0.291	.003	.001	3	4
URINARY_TRACT	PXMP2 →	+1.017	+0.270	.005	<.001	3	4
BLOOD_Leukemia	SNTA1 →	+1.528	+0.251	.003	<.001	3	4
BLOOD_Leukemia	CHCHD5 →	-1.573	-0.180	<.001	.001	3	4
BLOOD_Leukemia	FUT4 →	-1.297	-0.184	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055093 vs EIF4E3 — CNS

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