Phospholipid homeostasis

Across TCGA cell cohorts, RNA activity of the Phospholipid homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RCN3, HS3ST3A1, and CAVIN3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phospholipid homeostasis activity versus RCN3 in CNS (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RCN3 →	+3.873	+1.935	<.001	<.001	3	7
BONE	HS3ST3A1 →	+4.725	+1.806	<.001	<.001	3	5
BONE	CAVIN3 →	+4.762	+1.873	.001	<.001	3	5
BONE	WNT5B →	+3.877	+1.676	.001	.006	3	4
STOMACH	RWDD2B →	-0.569	-1.024	.007	.002	3	4
STOMACH	SLC22A15 →	+1.517	+1.097	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055091 vs RCN3 — CNS

Explore this scatter interactively →