Lipid homeostasis

Across TCGA patient cohorts, RNA activity of the Lipid homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TEDC2, FAM72A, and NT5E, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid homeostasis activity versus TEDC2 in BRCA (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TEDC2 →	-0.812	-0.182	<.001	<.001	3	5
BRCA	FAM72A →	-0.472	-0.126	.003	.004	3	5
BRCA	NT5E →	+0.921	+0.157	<.001	<.001	3	4
BRCA	HAUS1 →	-0.572	-0.123	.002	.006	3	4
HNSC	HELLS →	-0.590	-0.145	.005	.004	3	4
HNSC	SGO1 →	-0.619	-0.149	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055088 vs TEDC2 — BRCA

Explore this scatter interactively →