Lipid homeostasis

Across TCGA cell cohorts, RNA activity of the Lipid homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AXL, ABCA1, and CLMP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AXL grouped by Lipid homeostasis-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	AXL →	-2.389	-0.653	.002	.007	3	5
OVARY	ABCA1 →	-1.338	-1.065	.008	.003	3	4
OVARY	CLMP →	-2.364	-0.881	.001	.002	3	4
KIDNEY	LGALS1 →	-1.295	-1.087	<.001	<.001	3	4
LUNG_SCLC	DHTKD1 →	+1.304	+0.213	.002	.002	2	5
BONE	GLIPR1 →	-3.025	-1.338	.009	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AXL by Lipid homeostasis activity — OVARY

Explore this box plot interactively →