Monoatomic anion homeostasis

Across TCGA patient cohorts, RNA activity of the Monoatomic anion homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WRNIP1, RILPL2, and SOD2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monoatomic anion homeostasis activity versus WRNIP1 in LSCC (Pearson r = -0.55).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WRNIP1 →	-0.454	-0.095	<.001	<.001	3	7
LSCC	RILPL2 →	+0.306	+0.082	<.001	<.001	3	6
LSCC	SOD2 →	+0.553	+0.092	<.001	<.001	3	6
GBM	BPTF →	-0.273	-0.079	<.001	<.001	3	6
GBM	GPX1 →	+0.338	+0.081	<.001	<.001	3	6
LSCC	HSD17B4 →	+0.467	+0.102	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055081 vs WRNIP1 — LSCC

Explore this scatter interactively →