Monoatomic anion homeostasis

Across TCGA cell cohorts, RNA activity of the Monoatomic anion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC12A2, HOXA2, and SIX4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monoatomic anion homeostasis activity versus SLC12A2 in STOMACH (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SLC12A2 →	+2.247	+1.168	<.001	.002	2	7
URINARY_TRACT	HOXA2 →	-1.574	-2.037	.001	<.001	3	6
LUNG_NSCLC_LUSC	SIX4 →	-1.119	-2.132	.003	<.001	3	5
STOMACH	S100P →	+6.782	+1.238	<.001	<.001	3	5
STOMACH	GPX2 →	+6.105	+1.140	<.001	.003	3	5
LUNG_NSCLC_LUAD	ELF3 →	+2.720	+1.039	.007	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055081 vs SLC12A2 — STOMACH

Explore this scatter interactively →