Sodium ion homeostasis

Across TCGA patient cohorts, RNA activity of the Sodium ion homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RIF1, DDX21, and SMCHD1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sodium ion homeostasis activity versus RIF1 in LSCC (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RIF1 →	-0.342	-0.042	<.001	<.001	3	8
LUAD	DDX21 →	-0.517	-0.073	<.001	<.001	3	7
GBM	SMCHD1 →	-0.298	-0.039	.002	.002	3	7
LSCC	WDR36 →	-0.387	-0.069	<.001	<.001	3	7
LUAD	WDR75 →	-0.354	-0.077	<.001	<.001	3	7
LUAD	BOP1 →	-0.302	-0.089	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055078 vs RIF1 — LSCC

Explore this scatter interactively →