Sodium ion homeostasis

Across TCGA cell cohorts, RNA activity of the Sodium ion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CARS2, PRPF18, and MAP3K2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CARS2 grouped by Sodium ion homeostasis-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CARS2 →	-0.582	-1.667	.007	<.001	3	4
LARGE_INTESTINE	PRPF18 →	+0.628	+1.229	.004	<.001	3	4
LIVER	MAP3K2 →	+0.760	+0.524	.008	<.001	3	4
SOFT_TISSUE	SLC39A9 →	-0.558	-1.137	.003	.006	3	3
STOMACH	ABCE1 →	+0.671	+0.937	.007	.007	3	3
STOMACH	KIF18B →	+1.136	+0.938	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CARS2 by Sodium ion homeostasis activity — BLOOD_Lymphoma

Explore this box plot interactively →