Sodium ion homeostasis

Across TCGA cell cohorts, RNA activity of the Sodium ion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP1A1, CYP39A1, and PARP14, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sodium ion homeostasis activity versus ATP1A1 in SOFT_TISSUE (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ATP1A1 →	+1.212	+0.454	<.001	<.001	3	7
OESOPHAGUS	CYP39A1 →	+1.318	+0.343	.004	.006	3	6
BONE	PARP14 →	+2.248	+0.368	.007	.007	2	7
BLOOD_Leukemia	FAM171A2 →	-0.833	-0.333	.002	.005	3	5
BREAST	ATP1B1 →	+1.538	+0.368	.004	.004	3	5
LARGE_INTESTINE	MGST2 →	+1.347	+0.254	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055078 vs ATP1A1 — SOFT_TISSUE

Explore this scatter interactively →