Potassium ion homeostasis

Across TCGA patient cohorts, RNA activity of the Potassium ion homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BPTF, DHX16_S160, and CBX1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Potassium ion homeostasis activity versus BPTF in BRCA (Pearson r = -0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BPTF →	-0.342	-0.035	<.001	.007	3	7
LSCC	DHX16_S160 →	-0.506	-0.083	<.001	<.001	3	7
LSCC	CBX1 →	-0.418	-0.072	.001	<.001	3	7
GBM	SNRNP200 →	-0.236	-0.049	<.001	<.001	3	6
LSCC	ZNF318 →	-0.467	-0.077	<.001	<.001	3	6
LSCC	SNRNP40 →	-0.232	-0.076	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055075 vs BPTF — BRCA

Explore this scatter interactively →