Potassium ion homeostasis

Across TCGA patient cohorts, RNA activity of the Potassium ion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP13A4, EHF, and RRM2B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Potassium ion homeostasis activity versus ATP13A4 in PDAC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ATP13A4 →	+0.871	+0.715	<.001	<.001	3	4
LSCC	EHF →	+1.240	+0.977	<.001	<.001	3	4
BRCA	RRM2B →	+0.473	+0.460	.003	<.001	3	4
LUAD	EMC2 →	+0.265	+0.724	.006	<.001	3	3
LUAD	NCALD →	+0.669	+0.781	.003	<.001	3	3
GBM	SLC8A2 →	+0.827	+0.630	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055075 vs ATP13A4 — PDAC

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