Potassium ion homeostasis

Across TCGA cell cohorts, RNA activity of the Potassium ion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPSM1, ATP1B1, and ATP1A1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Potassium ion homeostasis activity versus GPSM1 in LARGE_INTESTINE (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GPSM1 →	-1.124	-0.227	.003	.006	3	7
STOMACH	ATP1B1 →	+3.378	+0.440	.004	<.001	3	6
CNS	ATP1A1 →	+1.187	+0.365	<.001	<.001	3	6
LARGE_INTESTINE	GATA6 →	+1.513	+0.259	.001	.001	3	5
LARGE_INTESTINE	IKBIP →	-1.535	-0.449	<.001	<.001	3	5
STOMACH	SEL1L3 →	+3.165	+0.392	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055075 vs GPSM1 — LARGE_INTESTINE

Explore this scatter interactively →