Copper ion homeostasis

Across TCGA patient cohorts, RNA activity of the Copper ion homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STRBP, DARS2, and AKAP13_S2498, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Copper ion homeostasis activity versus STRBP in LSCC (Pearson r = 0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	STRBP →	+0.456	+0.033	.004	.002	2	7
LSCC	DARS2 →	+0.372	+0.038	.001	<.001	3	6
LUAD	AKAP13_S2498 →	-0.365	-0.029	<.001	.002	3	6
HNSC	MICAL1 →	-0.303	-0.074	<.001	<.001	3	6
HNSC	ARHGEF6 →	-0.323	-0.062	<.001	.001	3	6
COAD	RASSF2 →	-0.345	-0.027	.003	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055070 vs STRBP — LSCC

Explore this scatter interactively →