Copper ion homeostasis

Across TCGA cell cohorts, RNA activity of the Copper ion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S100A3, C15orf65, and IFNLR1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, S100A3 grouped by Copper ion homeostasis-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	S100A3 →	-1.809	-1.173	.001	<.001	3	5
LUNG_NSCLC_LUAD	C15orf65 →	-0.948	-0.976	.001	<.001	3	4
URINARY_TRACT	IFNLR1 →	+1.912	+1.644	.002	<.001	3	4
SKIN	PPP1R14C →	+1.269	+0.928	.002	<.001	3	3
SKIN	ERV3-1 →	-0.779	-0.958	<.001	<.001	3	3
SKIN	GPC4 →	+1.176	+0.781	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

S100A3 by Copper ion homeostasis activity — OVARY

Explore this box plot interactively →