Copper ion homeostasis

Across TCGA cell cohorts, RNA activity of the Copper ion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP3R1, AREG, and PECR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Copper ion homeostasis activity versus PPP3R1 in LUNG_NSCLC_LUSC (Pearson r = -0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PPP3R1 →	-0.900	-0.305	.006	.001	3	5
PANCREAS	AREG →	+2.773	+0.229	<.001	.006	3	4
UPPER_AERODIGESTIVE_TRACT	PECR →	-1.014	-0.243	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	ACADM →	-1.440	-0.262	.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	TNFRSF10D →	+2.090	+0.280	.005	.003	3	4
STOMACH	LAMA3 →	+4.545	+0.311	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055070 vs PPP3R1 — LUNG_NSCLC_LUSC

Explore this scatter interactively →